Gene copy number variation in natural populations of Plasmodium falciparum in Eastern Africa

BMC Genomics

Table 2 Functional gene categories showing significant enrichment for CNVs

Functional gene set	No. of genes in CNVs	Total no. of genes in gene set	Nominal	Adjusted
Functional gene set	No. of genes in CNVs	Total no. of genes in gene set	P-value^a	P-value^b
Deletions
Exported proteins - PHISTs	8	48	< 0.001	< 0.001
Characteristics of Plasmodium falciparum export proteins that remodel infected erythrocyte	5	35	< 0.001	0.043
Glycolysis	4	27	0.001	0.10
Exported proteins - Unique	6	72	0.0025	0.10
Utilization of phospholipids	4	40	0.005	0.26
Amplifications
Rab and other proteins involved in intracellular traffic	3	14	0.009	1
RNA binding genes	12	173	0.01	1

ISSN: 1471-2164