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Fig. 2 | BMC Genomics

Fig. 2

From: A genome-wide assessment of conserved SNP alleles reveals a panel of regulatory SNPs relevant to the peripheral nerve

Fig. 2

Activity of a pilot set of putative regulatory elements on chromosomes 21, 22, and X in Schwann cells and motor neurons. 144 genomic regions containing the major SNP allele were cloned upstream of a luciferase reporter gene and tested in the forward (blue bars) or reverse (red bars) orientation in S16 (a) and MN1 cells (b). The activity of each genomic segment is expressed relative to a control vector with no genomic insert (first bar in each frame). Dashed lines indicate a five-fold increase in activity over the control vector, and error bars show standard deviations

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