A genome-wide assessment of conserved SNP alleles reveals a panel of regulatory SNPs relevant to the peripheral nerve

Table 3 Four genomic segments harboring a SOX10 consensus sequence display regulatory activity in Schwann cells

Region	Fold-increase Forward	Fold-increase Reverse	Coordinates (hg18)^a	rs Number	MAF^b
rSOX-1	2.57	8.29	chr2:44834620-44834625	rs3738980	0.3035
rSOX-4	4.83	25.96	chr6:22818474-22818479	rs16886790	0.2001
rSOX-6	0.33	11.01	chr6:98692222-98692227	rs17814604	0.1014
rSOX-22	14.12	4.44	chr16:53169712-53169728	rs1186802	0.4219

^aCoordinates for the conserved SOX10 monomeric sites for rSOX-1, −4, and − 6 and the dimeric site for rSOX-22
^bMAF is the minor allele frequency from the 1000 Genomes Project [72]

ISSN: 1471-2164