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Fig. 3 | BMC Genomics

Fig. 3

From: Bidirectional promoters exhibit characteristic chromatin modification signature associated with transcription elongation in both sense and antisense directions

Fig. 3

Statistical analysis of histone enrichment on bidirectional promoters classified based on transcriptional status. The figure depicts violin plots for the distributions of enrichment of various histone modifications at bidirectional promoters. The labels High_exp, Low_exp indicate gene gests that are part of an asymmetrically expressing pair with High_exp being the partner gene with high expression and Low_exp being the partner with low expression. The labels Similar_left and Similar_right indicate genes from a symmetrically expressing bidirectional pair where left and right indicate direction of transcription relative to the midpoint of the intergenic region respectively. H4K4me3 for CD4+T cells (n = 187 gene pairs for asymmetric, n = 58 gene pairs for symmetric) and H1 ES cells (n = 319 gene pairs for asymmetric, n = 65 gene pairs for symmetric) (a), H3K27Ac occupancy in CD4+ T cells and H1 ES cells (b) was analyzed. The elongation associated marks H3K436me3 (panel c Left) and H3K79me1 (panel c Right) were analyzed in H1 ES cells. Enrichment of transcription initiation mark H3K4me3 exhibits significant difference in asymmetric gene pairs in both cell types. For H1 ES cells occupancies of all histone modifications tested reveal different profiles in asymmetric and symmetric genes

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