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Table 8 Top 20 human genes with highest number of human-specific intronic motifs from analysis of HAR regions

From: Motifome comparison between modern human, Neanderthal and Denisovan

Refseq ID

Gene name

Function

Number of motifs

NP_955533.1

PRDM16

PR domain containing 16 isoform 2

81

NP_689957.3

SDK1

protein sidekick-1 isoform 1

81

NP_570858.2

PTPRN2

receptor-type tyrosine-protein phosphatase N2 isoform 3

81

NP_570857.2

PTPRN2

receptor-type tyrosine-protein phosphatase N2 isoform 2

81

NP_115821.2

MEGF11

multiple epidermal growth factor-like domains protein 11 precursor

80

NP_113654.3

TRAPPC9

trafficking protein particle complex 9

80

NP_071407.4

CDH23

cadherin-23 isoform 1 precursor

79

NP_071397.2

PRDM16

PR domain containing 16 isoform 1

79

NP_065828.2

SORCS2

VPS10 domain-containing receptor SorCS2 precursor

79

NP_060021.1

GRID1

glutamate receptor ionotropic, delta-1 precursor

78

NP_056030.1

CAMTA1

calmodulin-binding transcription activator 1 isoform 1

78

NP_055729.2

AGAP1

arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform 2

77

NP_003362.2

VAV2

guanine nucleotide exchange factor VAV2 isoform 2

77

NP_002838.2

PTPRN2

receptor-type tyrosine-protein phosphatase N2 isoform 1 precursor

77

NP_001785.2

CDH4

cadherin-4 isoform 1 preproprotein

77

NP_001127870.1

VAV2

guanine nucleotide exchange factor VAV2 isoform 1

77

NP_001104488.1

NAV2

neuron navigator 2 isoform 3

77

NP_001085.2

ASIC2

acid-sensing ion channel 2 isoform MDEG1

77

NP_001076044.1

RBFOX3

RNA binding protein fox-1 homolog 3

77

NP_001032208.1

AGAP1

arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform 1

77

  1. Statistically significant intron motifs were found in 20 intronic HARs between modern human and Denisovan. Eighty-two of them were shown to be specific to modern human. These are the top 20 genes with the highest number of these human-specific intron motifs (at least 77 of them) in their introns. Listed are the genes’ Refseq ID, their gene name, function and the number of motifs their introns contain