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Table 9 Biological processes found through GO term analysis

From: Motifome comparison between modern human, Neanderthal and Denisovan

GO term

Genes in database

Genes found

Expected

Fold enrichment

P-value

Single-organism developmental process

5316

61

27.63

2.21

8.94E-08

Developmental process

5402

61

28.08

2.17

1.84E-07

System development

4138

52

21.51

2.42

3.96E-07

Single-multicellular organism process

5509

61

28.63

2.13

4.41E-07

Anatomical structure development

5059

58

26.29

2.21

5.19E-07

Cell adhesion

1103

25

5.73

4.36

3.16E-06

Biological adhesion

1108

25

5.76

4.34

3.47E-06

Multicellular organism development

4733

54

24.6

2.2

5.41E-06

Single-organism process

12,622

94

65.6

1.43

2.04E-05

Multicellular organismal process

6584

64

34.22

1.87

3.08E-05

Nervous system development

2200

33

11.43

2.89

1.04E-04

Cell-cell adhesion

680

18

3.53

5.09

1.27E-04

Cellular developmental process

3501

42

18.2

2.31

3.60E-04

Cell differentiation

3425

41

17.8

2.3

6.09E-04

Regulation of multicellular organismal process

2656

35

13.8

2.54

8.50E-04

Homophilic cell adhesion via plasma membrane adhesion molecules

155

9

0.81

11.17

1.18E-03

Generation of neurons

1391

24

7.23

3.32

1.37E-03

Cell-cell adhesion via plasma-membrane adhesion molecules

212

10

1.1

9.08

1.57E-03

Regulation of cellular component organization

2292

31

11.91

2.6

3.40E-03

Neurogenesis

1487

24

7.73

3.11

4.57E-03

Regulation of developmental process

2263

30

11.76

2.55

8.48E-03

Neuron differentiation

937

18

4.87

3.7

1.38E-02

Cell development

1476

23

7.67

3

1.50E-02

Regulation of biological quality

3560

39

18.5

2.11

1.51E-02

Regulation of multicellular organismal development

1714

25

8.91

2.81

1.60E-02

Anatomical structure morphogenesis

1959

27

10.18

2.65

1.66E-02

Single organism signaling

5262

50

27.35

1.83

1.69E-02

Signaling

5266

50

27.37

1.83

1.73E-02

Regulation of cell projection organization

586

14

3.05

4.6

1.92E-02

Single-organism cellular process

9804

75

50.96

1.47

2.22E-02

Regulation of nervous system development

782

16

4.06

3.94

2.52E-02

Multicellular organismal signaling

129

7

0.67

10.44

4.71E-02

  1. The top 189 transcripts, which had the highest number of human-specific intron motifs mapped to 135 UniProt IDs, which also mapped to 261 specific gene names. GO term analysis was performed with these genes at the Panther website. Shown below are the top 32 biological process GO terms found in this GO analysis
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BMC Genomics

ISSN: 1471-2164

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