Fig. 4
From: CLICK: one-step generation of conditional knockout mice
Schematic representation of various mutations generated by CLICK. Two gRNAs and Cas9 formed double-strand breaks (DSB) on each targeted site or a large deletion between the two sites. DSBs repaired by NHEJ caused indel mutations or LD. DSBs elicited a single loxP insertion or floxed allele by HDR repair