Table 5 Summary of upregulated genes in the most-recurrent KEGG subcategories in both and specific comparisons (FDR and p-value ≤0.05)
KEGG Category | Status | +1vs-14 time comparison | -2vs-14 time comparison | Both time comparisons |
|---|---|---|---|---|
Lipid Metabolism | upregulated | ALDH2, HMGCS1, HSD11B1, SCD, ACSL3, FAXDC2, SGMS2, SC5D, 403,334, ACACB, SQLE, MSMO1, CYP2J2, CERS4, CYP2J34, LCLAT1, DHCR24, 100,233,182, PLPP3, FADS2, 100,170,845, 100,517,533, ACAT2, MGLL, CYP2D25, TM7SF2, ACADM, ARSA, PNPLA2, GLA, SMPD1, PTGS1, LPCAT3, GPCPD1, PAFAH2, ACADS, NSDHL, PLA2G12A, KDSR, ECI2, GBA2, COMT, 100515577 | CYP1A1, 100,157,065, GPAM, GPD2, SGMS1, CDIPT, DGAT1 | GGT1, 397,097, FADS1, AGPAT1, NEU1, GPAT4, CEPT1, HSD17B7, CDS2, PLA2G16, 100,522,126, 100,522,145, 100,522,692, GPAT3, 100,625,138, 100,625,332, 100,738,292 |
Endocrine System | upregulated | CYP1A1, PYGB | 396,835, CD14, FXYD2, FOS, HK2, RCAN1, SH2B2, PFKFB2, STAT3, ACACB, PHKG1, ITGB3, HSPA5, OXTR, CYP2J2, PLN, PLCD3, SEC11C, CYP2J34, HSP90B1, MYL9, CPEB4, 100,514,493, ITGA11, RRAS, CREB3L2, CPEB3, CFL2, NFATC2, CTSB, SEC61G, SRP54, SPCS3, PRKCI, ITGA2, PLCD1, JUN, DIAPH1, SEC63, PRKAB2, SP1, BCAR1, B2M, 106,504,143, PRKAB1, PIKFYVE, KAT2B, CREB3, PRKCD, STAT1, RYR2, 100,522,756, 396,848, CASP9, PHKG2, JAK2, ITGAV, SRP68, SRP68, PPP1CB, ITPR3, SOCS6, IFI30, PAK1, PPP1R12C, ELK1, 100,517,270, RHOA | CTSV, KCNJ2, NOS3, PCK2, CSN2, FOXO3, MTOR, NCOA2, SPCS1, SRC, SEC61A1, HSD17B7, PDIA3, MAPK14, CALR, SEC61B, RPTOR, SRPRA, CREB3L1, CANX, VAV1, 100,522,176, PDIA4, GNA13, 100,523,015, 100,523,202, EEF2K, MRAS |