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Table 1 Tests for difference of FS mutation incidence rate between resistant and sensitive strains for each drug within 1110 MTB strains

From: Whole genome sequencing data of 1110 Mycobacterium tuberculosis isolates identifies insertions and deletions associated with drug resistance

Drug Ratio of strains with FS mutation within resistant strainsa Ratio of strains with FS mutation within sensitive strainsb Adjusted Chi-square p-value Adjusted Fisher’s exact p-value
AMI 0.83 0.77 0.323 0.477
CAP 0.82 0.77 0.323 0.471
EMB 0.89 0.72 2.64E-09 8.46E-10
ETH 0.93 0.77 0.017 0.020
INH 0.87 0.63 3.08E-15 3.74E-15
KAN 0.86 0.77 0.323 0.477
MOX 0.90 0.76 0.002 0.001
OFX 0.89 0.76 4.63E-04 3.41E-04
PRO 0.86 0.76 0.006 0.006
PZA 0.83 0.77 0.094 0.148
RIF 0.87 0.67 2.43E-14 2.78E-14
STR 0.86 0.68 1.35E-11 1.62E-11
  1. Both chi-square test and fisher exact test were used to test the difference of the incidence rate between resistant and sensitive strains for each drug. The drugs with both chi-square p-value and fisher p-value lower than 0.01 were highlighted. FDR method was used to do multiple testing correction
  2. aIncidence rate of FS mutation within resistant strains, which equals to the number of resistant strains with FS mutations divided by the total number of resistant strains of a certain drug
  3. bIncidence rate of FS mutation within sensitive strains, which equals to the number of sensitive strains with FS mutations divided by the total number of sensitive strains of a certain drug