Whole genome sequencing data of 1110 Mycobacterium tuberculosis isolates identifies insertions and deletions associated with drug resistance

Table 2 Overlapping of region markers (genes/IGRs) and point markers (FS mutations and IGR indels)

Region markers	Mutation type	Point markers	Functions
ndhA-Rv0393	Intergenic region	472,711:T:TTTGTGGGCC^a	NADH dehydrogenase NdhA, hypothetical protein
rseA-htrA	Intergenic region	1,365,837:C:CGG	anti-sigma E factor RseA, serine protease HtrA
Rv2081c	Frameshift mutation	p.Val105fs^b	transmembrane protein
whiB6-Rv3863	Intergenic region	4,338,595:GC:G	transcriptional regulator WhiB6, hypothetical protein
vapC2-Rv0302	Intergenic region	364,498:TG:T	ribonuclease VapC2, transcriptional regulator
pncA	Frameshift mutation	p.Val131fs	pyrazinamidase/nicotinamidase PncA
Rv0759c-Rv0760c	Intergenic region	854,252:GC:G	hypothetical protein, hypothetical protein
mce2A-mce2C	Intergenic region	688,792:T:TG	Mce family protein Mce2A, Mce family protein Mce2C
Rv3750c-serX	Intergenic region	4,198,611:CG:C	excisionase, tRNA

The content in the 3rd column included “Location_in_genome:reference_allele:alternative_allele” representing IGR indels and “Change of amino acid” representing for FS mutations
^aLocation_in_genome:reference_allele:alternative_allele
^bChange of amino acid

ISSN: 1471-2164