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Fig. 7 | BMC Genomics

Fig. 7

From: Waveband specific transcriptional control of select genetic pathways in vertebrate skin (Xiphophorus maculatus)

Fig. 7

Panel (a) Results from X. maculatus skin after exposure to 510–520 nm (High) of light, or 510–520 nm of light immediately followed by exposure to 350–360 nm of light. When exposed first to 510 nm of light and then 350 nm of light (High-Low) the effect observed mimics the solely exposed 510–520 nm waveband results where 18 upstream regulators are shared by the two exposure types. Dominate functions effected by either exposure regimen effect apoptosis, necrosis, cell proliferation, cellular organization, immune and inflammation response and lipid metabolism. Of all pathways modulated, only apoptosis is oppositely modulated; up (orange) following 510–520 nm exposure and down (blue) following the High-Low exposure. The numbers of genes showing modulated transcription in each functional pathway are indicated by the number inside of each red (up-modulated) and green (down-modulated) box. For complete gene lists of each upstream regulator see Additional file 6: Table S6a–d. Panel (b) X. maculatus exposed to 350–360 nm (Low) of light compared to X. maculatus exposed to 350–360 nm of light immediately followed by exposure to 510–520 nm (Low-High) of light. When exposed first to 350 nm of light and then 510 nm of light, the observed effects are quite different from the inverse “High-Low” exposure. In this case many fewer functional classes are effected, consistent with results from single exposure of 350–360 nm vs, 510–520 nm exposure. However, of the four upstream classes effected all are oppositely regulated by the Low-High exposure, compared to the 350–360 nm exposure except apoptosis. Apoptosis is up regulated by either 350–360 nm or the Low-High exposure regimen. Not only are the main functional groups oppositely modulated in the Low-High exposure, when compared to the 350–360 nm waveband, but also when compared to the High-Low exposure (510 followed by 350 nm, left). This suggests that although the light effect is largely muted, it is dominated by a unique set of gene regulators that oppositely effect the downstream cellular and metabolic functions. For complete gene lists of each upstream regulator see Additional file 6: Table S6a–d

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