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Table 5 Summary of differentially expressed genes related to cholesterol and long chain fatty acid pathways

From: Dietary aquaculture by-product hydrolysates: impact on the transcriptomic response of the intestinal mucosa of European seabass (Dicentrarchus labrax) fed low fish meal diets

Classification/Transcript   Gene fold change as compared to the low fish meal diet (FM5)
FM20 FM5 + 5% TH FM5 + 5% SH FM5 + 5% MH
Cholesterol related
 TRINITY DN71881 c0 g2 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase     −3.00
 TRINITY DN67458 c2 g3 Delta(14)-sterol reductase     −2.75
 TRINITY DN76391 c4 g1 Farnesyl pyrophosphate synthase −2.98   −2.7 −5.68
 TRINITY DN71950 c2 g1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic −1.93    −3.19
 TRINITY DN79342 c1 g2 Lanosterol 14-alpha demethylase −1.85    −2.06
 TRINITY DN75940 c1 g2 Lanosterol synthase −2.65    −3.74
 TRINITY DN76284 c0 g1 Lathosterol oxidase     −2.68
 TRINITY DN72542 c3 g1 Neutral cholesterol ester hydrolase 1 2.61    
 TRINITY DN66926 c0 g1 Squalene monooxygenase     −3.82
 TRINITY DN78143 c3 g1 Squalene synthase     −2.64
 TRINITY DN71672 c0 g3 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating     −3.59
 TRINITY DN75298 c0 g2 Transmembrane protein 97     −2.25
Fatty acid related
 TRINITY DN70866 c4 g9 2,4-dienoyl-CoA reductase, mitochondrial     −1.92
 TRINITY DN78203 c0 g3 3-ketoacyl-CoA thiolase, mitochondrial     −2.37
 TRINITY DN74534 c0 g3 Acetoacetyl-CoA synthetase     −4.95
 TRINITY DN74255 c1 g3 Acetyl-CoA carboxylase     −2.11
 TRINITY DN72189 c4 g3 Acyl-CoA desaturase 1.78    5.40
 TRINITY DN70036 c1 g2 Alkylglycerol monooxygenase 1.99    
 TRINITY DN77637 c3 g4 ATP-binding cassette sub-family D member 2     −3.41
 TRINITY DN74635 c4 g2 Elongation of very long chain fatty acids protein 4     −2.71
 TRINITY DN73852 c1 g2 Elongation of very long chain fatty acids protein 6     −3.96
 TRINITY DN79046 c1 g4 Fatty acid hydroxylase domain-containing protein 2     1.94
 TRINITY DN79053 c1 g4 Fatty acid synthase     −3.33
 TRINITY DN79341 c1 g1 Fatty acid-binding protein, brain 4.26    
 TRINITY DN56507 c0 g1 Fatty acid-binding protein, intestinal     −1.88
 TRINITY DN79266 c1 g10 Fatty acid-binding protein, liver-type     −2.17
 TRINITY DN78522 c0 g2 Long-chain-fatty-acid--CoA ligase 4 −1.89    
 TRINITY DN75220 c0 g3 Methylsterol monooxygenase 1 −2.26    −2.31
 TRINITY DN78695 c0 g7 Perilipin-2 −3.04    
 TRINITY DN78695 c0 g2 Perilipin-2 −3.15   −2.3  
 TRINITY DN72627 c0 g1 Phosphatidate phosphatase LPIN1     −4.12
 TRINITY DN72627 c1 g3 Phosphatidate phosphatase LPIN2 2.00    
 TRINITY DN71726 c1 g1 Sodium-dependent lysophosphatidylcholine symporter 1-B     −3.38
 TRINITY DN72471 c1 g2 Trifunctional enzyme subunit beta, mitochondrial     −2.18
 TRINITY DN67880 c1 g2 Very long-chain acyl-CoA synthetase    2.1 3.01
 TRINITY DN71905 c5 g2 Very long-chain acyl-CoA synthetase 1.93    
 TRINITY DN76293 c0 g2 Very long-chain acyl-CoA synthetase 1.87    
  1. Values correspond to fold changes between diets and the low fish meal control diet. Positive values indicate upregulation, and negative values down regulation. FM5 5% fish meal diet, FM20 20% fish meal diet, TH tilapia hydrolysate diet, SH shrimp hydrolysate diet, MH mixed hydrolysate diet