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Fig. 6 | BMC Genomics

Fig. 6

From: Gene expression profiling in the developing secondary palate in the absence of Tbx1 function

Fig. 6

Molecular associations linking Tbx1 with Fgf and Shh signaling in the developing palate. Tbx1 in the palatal shelf epithelium is downstream of Fgf signaling, the ligand/s and source (epithelium/ mesenchyme) are currently unknown. Shh-Fgf10-Fgfr2b epithelial-mesenchymal reciprocal signaling [54] antagonizes Bmp4 [55] and induces Pax9 indirectly through the induction of Osr2 [55, 82]. We and others [48] have demonstrated that Tbx1 acts to inhibit Bmp4 and induce Pax9. It has been suggested that Tbx1 activity is required for Fgf8 induction in the epithelium and Fgf10 inhibition in the mesenchyme [47]; however, we and others [48] have found no evidence of this

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