Fig. 1

Predictions for the production of essential metabolites by symbionts in the bacteriocyte in an environment simulating substrates produced by the host (a) and in an environment simulating substrates produced by the host and its obligatory symbiont Portiera (b). Only essential metabolites that are not directly provided in the environment are shown. Cell color: white/black/pink – no synthesis /synthesis/synthesis unique to host-Portiera environment (b). Color on the left side indicates the super-pathway classification of each metabolite. P, C, H, R and W represent Portiera, Cardinium, Hamiltonella, Rickettsia and Wolbachia, respectively. As identical profiles were retrieved for the two Rickettsia and two Hamiltonella genomes, for simplicity only a single representative is shown