Fig. 3
Core genes SigX regulon of the mitis group. Synteny conservation of S. mitis type strain and SK321, S. pneumoniae, Streptococcus gordonii and S. sanguinis. Red pentagons correspond to genes immediately downstream of a SigX box. Genes induced by competence, black borders; upregulated genes oriented antisense to the gene downstream of a SigX box, dashed black borders; no change in gene expression, borderless faded colors; orthologues in each of the 15 gene groups are represented by similar colors; no orthologues in the regions analyzed, gray pentagons. SMIT*, S. mitis type strain upregulated sequences in TSB and C + YYB media, gene locus tag as in GenBank (accession no. AEDX00000000); SK321 gene locus tag as in GenBank (accession no. AEDT00000000). SP1, S. pneumoniae Rx [9]; gene locus tag as in GenBank (S. pneumoniae TIGR4, accession no. AE005672). SP2, S. pneumoniae R6 [28]; gene locus tag as in GenBank (S. pneumoniae TIGR4, accession no. AE005672). SP3, S. pneumoniae G54 [50]; gene locus tag as in GenBank (S. pneumoniae G54, accession no. CP001015). SGO3, S. gordonii Challis [36]; gene locus tag as in GenBank (S. gordonii Challis, accession no. CP000725). SSA4, S. sanguinis SK36 [31]; gene locus tag as in GenBank (accession no. CP000387.1). a, b, c, d Upregulation was not > 2-fold. The image was modified from [29]