Fig. 1

First layer protein networks. a. FTD (blue nodes, 272 nodes and 304 edges); b. PS (orange nodes, 140 nodes and 133 edges); c. PD (red nodes, 286 nodes and 332 edges); d. Combination of a-b-c into a single network: the grey nodes represent proteins that are shared between a-b, a-c, b-c or a-b-c. Networks are reported as organic layout to highlight clustering properties. e. Seeds + first and second layer interactors combined in the final network, purple = seeds; green = IIHs