Fig. 4

Gene Ontology (GO) and KEGG analysis of D3 specific DMRs. Gene Ontology (GO) and pathway enrichment analysis of differentially methylated regions using Enrichr and DAVID under default parameters. The bar charts show the most relevant and significantly enriched terms. Terms that are highly related to CHD are marked in blue. The x-axis represents the –log10 of the enrichment p-value. The y-axis represents the enriched terms in GO or KEGG databases. a GO enrichment analysis of genes associated with differentially methylated regions in 2 kb upstream of genes. b GO enrichment analysis of genes associated with differentially methylated regions in gene body. c GO enrichment analysis of TFs whose binding sites are differentially methylated. d KEGG pathway enrichment analysis of TFs whose binding sites are differentially methylated