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Table 3 List of functional groups and related liver DEGs from C. semilaevis in response to long-term hypotonic stress

From: Liver transcriptome analysis reveals extensive transcriptional plasticity during acclimation to low salinity in Cynoglossus semilaevis

Function group Gene name Gene ID Gene function Log2(fold change)
Metabolism
ebp XM_008318098.1 emopamil binding protein (sterol isomerase) + 3.73
lss XM_008328991.1 lanosterol synthase (2%2C3-oxidosqualene-lanosterol cyclase) + 3.31
cyp51 XM_008331912.1 lanosterol 14-alpha demethylase + 3.12
fdps XM_008323163.1 farnesyl diphosphate synthase + 2.99
hmgcs1 XM_008324442.1 hydroxymethylglutaryl-CoA synthase%2C cytoplasmic-like + 2.77
pmvk XM_008322893.1 phosphomevalonate kinase + 2.54
acat2 XM_008313119.1 acetyl-CoA acetyltransferase 2 + 2.53
dhcr24 XM_008307100.1 24-dehydrocholesterol reductase + 2.39
msmo1 XM_008317461.1 methylsterol monooxygenase 1 + 2.11
dhcr7 XM_008309911.1 7-dehydrocholesterol reductase + 1.89
sc5d XM_008333068.1 sterol-C5-desaturase%2C transcript variant X1 + 1.83
LOC103396997 XM_008335243.1 endothelial lipase-like + 1.74
hmgcr XM_008335608.1 3-hydroxy-3-methylglutaryl-CoA reductase + 1.74
mvk XM_008335531.1 mevalonate kinase + 1.54
LOC103397733 XM_008336101.1 endothelial lipase-like + 1.54
idh1 XM_008327862.1 isocitrate dehydrogenase 1 (NADP+)%2C soluble + 1.48
LOC103395808 XM_008333603.1 3-keto-steroid reductase-like + 1.45
abat XM_008330509.1 4-aminobutyrate aminotransferase −2.54
acy1 XM_008319784.1 aminoacylase 1 −1.87
ddc XM_008323903.1 dopa decarboxylase (aromatic L-amino acid decarboxylase) − 1.82
LOC103377813 XM_008308777.1 alkaline phosphatase-like −1.79
LOC103389307 XM_008324669.1 bile salt-activated lipase-like −1.73
LOC103388276 XM_008323191.1 pyruvate kinase PKM-like −1.72
LOC103389284 XM_008324640.1 bile salt-activated lipase-like −1.69
LOC103378976 XM_008310359.1 phospholipase D1-like −1.66
gamt XM_008333805.1 guanidinoacetate N-methyltransferase −1.64
LOC103387723 XM_008322480.1 inactive pancreatic lipase-related protein 1-like −1.62
LOC103399583 XM_008338252.1 aminoacylase-1-like −1.61
LOC103392251 XM_008328834.1 uricase-like −1.58
LOC103396493 XM_008334595.1 pancreatic alpha-amylase-like −1.54
LOC103390352 XM_008326174.1 UDP-glucuronosyltransferase 2A1-like%2C transcript variant X3 −1.31
LOC103381542 XM_008313955.1 neutral alpha-glucosidase C-like −1.20
Osmoregulation and ion transport
LOC103392748 XM_008329462.1 chromodomain-helicase-DNA-binding protein 1-like + 1.95
LOC103394918 XM_008332394.1 sodium-dependent dopamine transporter-like + 1.38
slc6a6 XM_008319443.1 solute carrier family 6 (neurotransmitter transporter)%2C member 6%2C transcript variant X1 −1.95
rem2 XM_008334215.1 RAS (RAD and GEM)-like GTP binding 2 −1.65
aqp10 XM_008323103.1 aquaporin 10 −1.58
LOC103391201 XM_008327377.1 ependymin-like −1.43
ankh XM_008308224.1 ANKH inorganic pyrophosphate transport regulator −1.33
LOC103389703 XM_008325232.1 sodium- and chloride-dependent GABA transporter 2-like −1.06
Signal transduction
LOC103385696 XM_008319660.1 taste receptor type 1 member 3 + 2.43
ghsr XM_008310310.1 growth hormone secretagogue receptor + 2.29
hmgcr XM_008335608.1 3-hydroxy-3-methylglutaryl-CoA reductase + 1.74
LOC103398491 XM_008337141.1 cocaine- and amphetamine-regulated transcript protein-like + 1.72
LOC103395241 XM_008332898.1 olfactory receptor 24-like −2.94
abat XM_008330509.1 4-aminobutyrate aminotransferase −2.54
LOC103390650 XM_008326578.1 ankyrin repeat and SOCS box protein 5-like −2.03
LOC103393547 XM_008330546.1 TANK-binding kinase 1-binding protein 1-like −1.86
LOC103383485 XM_008316623.1 ATP-binding cassette sub-family G member 2-like −1.81
LOC103378821 XM_008310167.1 galanin receptor type 1-like −1.78
LOC103381198 XM_008313433.1 scavenger receptor class A member 3-like −1.75
rem2 XM_008334215.1 RAS (RAD and GEM)-like GTP binding 2 −1.65
LOC103388851 XM_008324050.1 C-X-C chemokine receptor type 3-like −1.64
dpf3 XM_008312830.1 D4%2C zinc and double PHD fingers%2C family 3%2C transcript variant X3 −1.60
LOC103392251 XM_008328834.1 uricase-like −1.58
LOC103396858 XM_008335106.1 zinc finger protein 79-like −1.54
npr1 XM_008330816.1 natriuretic peptide receptor 1 −1.44
LOC103391201 XM_008327377.1 ependymin-like −1.43
LOC103398008 XM_008336483.1 phosphatidylinositol 3-kinase regulatory subunit alpha-like%2C transcript variant X1 −1.35
Immune response and stress response
ebp XM_008318098.1 emopamil binding protein (sterol isomerase) + 3.73
LOC103385685 XM_008319650.1 coiled-coil domain-containing protein 114-like + 2.20
LOC103398491 XM_008337141.1 cocaine- and amphetamine-regulated transcript protein-like + 1.72
endou XM_008320007.1 endonuclease%2C polyU-specific −2.03
LOC103393547 XM_008330546.1 TANK-binding kinase 1-binding protein 1-like −1.86
LOC103381198 XM_008313433.1 scavenger receptor class A member 3-like −1.75
LOC103388276 XM_008323191.1 pyruvate kinase PKM-like −1.72
fam163b XM_008324326.1 family with sequence similarity 163%2C member B −1.54
Cytoskeleton remodeling
srebf2 XM_008330306.1 sterol regulatory element binding transcription factor 2 + 1.42
ablim3 XM_008327647.1 actin binding LIM protein family%2C member 3 −1.88
LOC103393547 XM_008330546.1 TANK-binding kinase 1-binding protein 1-like −1.86
LOC103381198 XM_008313433.1 scavenger receptor class A member 3-like −1.75
LOC103398008 XM_008336483.1 phosphatidylinositol 3-kinase regulatory subunit alpha-like%2C transcript variant X1 −1.35