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Table 2 Associations between aggressive disease occurrence and SNPs using case-only analyses of two publicly available human prostate cancer GWAS

From: Modifier locus mapping of a transgenic F2 mouse population identifies CCDC115 as a novel aggressive prostate cancer modifier gene in humans

Cohort Gene Chr. Clinical Trait SNP ID t value P value OR (95% CI) Permutation P valuea
CGEMS CCDC115 2q21.1 Gleason Score rs11542411 3.05 0.0023 1.21 (1.07–1.36) 0.0024
DNAJC10 2q32.1 Gleason Score rs288324 −2.74 0.0062 0.87 (0.80–0.96) 0.0049
ZNF502 3p21.31 Metastasis Stage rs13321717 2.82 0.0049 1.05 (1.02–1.09) 0.005
GLRX 5q14 Gleason Score rs154447 2.85 0.0045 1.17 (1.05–1.30) 0.005
PKHD1 6p12.2 Gleason Score rs1266922 2.98 0.0029 1.17 (1.06–1.30) 0.0026
rs4711987 −2.72 0.0067 0.87 (0.79–0.96) 0.0072
rs9382070 −2.65 0.0081 0.88 (0.80–0.97) 0.0081
rs10948675 −2.64 0.0083 0.88 (0.80–0.97) 0.0061
rs1937147 −2.64 0.0083 0.88 (0.80–0.97) 0.0085
Metastasis Stage rs10484879 −2.95 0.0033 0.94(0.90–0.98) 0.0039
Tumor Stage rs10484879 −3.07 0.0022 0.93 (0.88–0.97) 0.0023
rs9370043 −2.77 0.0056 0.60 (0.41–0.86) 0.0048
rs1567215 −2.64 0.0083 0.61 (0.42–0.88) 0.0071
rs1326585 −2.60 0.0096 0.62 (0.43–0.89) 0.0104
OGFRL1 6q13 Tumor Stage rs12200732 −2.90 0.0038 0.89 (0.82–0.96) 0.0025
KCNQ5 6q14 Gleason Score rs9442812 −3.05 0.0023 0.65 (0.49–0.86) 0.0035
rs9351947 −2.73 0.0064 0.85 (0.76–0.96) 0.0059
rs9341399 −2.64 0.0085 0.58 (0.39–0.87) 0.0079
rs6952753 2.65 0.0081 1.32 (1.08–1.62) 0.0087
Nodal Stage rs9442812 3.61 0.0003 1.09 (1.04–1.14) 0.0004
Tumor Stage rs10046418 −2.97 0.0030 0.49 (0.31–0.78) 0.0036
STYXL1 7q11.23 Tumor Stage rs2840794 −2.88 0.0041 0.50 (0.31–0.80) 0.0036
ICPCG ZNF729 19p12 Aggressive vs. non-aggressive rs283168 2.65 0.0080 1.16 (1.04–1.30) 0.0087
RNF149 2q11.2 Aggressive vs. non-aggressive rs11677690 −2.64 0.0084 0.87 (0.78–0.96) 0.0096
GLRX 5q14 Aggressive vs. non-aggressive rs871775 −2.60 0.0093 0.83 (0.72–0.95) 0.0097
GSTA3 6p12.1 Aggressive vs. non-aggressive rs9474334 −2.59 0.0095 0.88 (0.80–0.97) 0.0086
PKHD1 6p12.2 Aggressive vs. non-aggressive rs1413917 2.86 0.0043 1.22 (1.06–1.40) 0.0062
KCNQ5 6q14 Aggressive vs. non-aggressive rs9446848 −3.14 0.0017 0.66 (0.51–0.85) 0.0016
rs9442891 −3.12 0.0018 0.66 (0.50–0.86) 0.0023
rs7772526 −3.11 0.0019 0.75 (0.63–0.90) 0.0022
rs6453613 3.04 0.0024 1.18 (1.06–1.31) 0.0023
rs6911751 −2.85 0.0044 0.77 (0.64–0.92) 0.0047
rs9446844 −2.84 0.0045 0.78 (0.65–0.92) 0.0047
rs6933440 −2.84 0.0046 0.78 (0.65–0.92) 0.0048
rs7748968 −2.82 0.0048 0.69 (0.53–0.89) 0.0054
rs9343009 −2.77 0.0056 0.78 (0.66–0.93) 0.0057
rs1935530 −2.65 0.0081 0.79 (0.66–0.94) 0.007
  1. aLD-block wide correction
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BMC Genomics

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