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Fig. 2 | BMC Genomics

Fig. 2

From: The whole transcriptome effects of the PPARα agonist fenofibrate on livers of hepatocyte humanized mice

Fig. 2

Fenofibrate does not cause any changes in basic parameters in hepatocyte humanized mice. Chimeric mice containing hepatocyte humanized livers were treated with 300 mg/kg fenofibrate daily for 4 days. Control mice received vehicle only. a mRNA expression of PPARα in 15 human liver biopsies collected during bariatric surgery and in liver samples from 3 chimeric mice containing hepatocyte humanized livers. b Bodyweight and liver weight. c Blood human albumin concentration. d Plasma concentration of glucose, triglycerides and cholesterol. Error bars represent SEM. N = 3 per group. e Histological examination of livers of chimeric mice containing hepatocyte humanized livers that received control or fenofibrate treatment. Hematoxilin and eosin staining was carried out according to standard protocols. Images are at 200× magnification. A section containing mouse hepatocytes is indicated (arrow). The mouse hepatocytes are present in clusters of non-steatotic cells, with the steatotic human hepatocytes taking up the remainder of the area. In addition, human hepatocytes show a light eosin staining while mouse hepatocytes are highly eosinophilic

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