Fig. 4

Distinct clustering of livers of control-treated and fenofibrate-treated hepatocyte humanized mice. Transcriptomics was performed on livers of chimeric mice containing hepatocyte humanized livers. Mice were treated with 300 mg/kg fenofibrate daily for 4 days (n = 3) or vehicle (control, n = 3). a Principle component analysis of transcriptomics data from the control- and fenofibrate-treated mice. The graph shows the clear separation of fenofibrate and control groups. b Hierarchical clustering of transcriptomics data from the control- and fenofibrate-treated mice. The dendogram reveals the distinct clustering and separation of the fenofibrate and control groups. c The top 20 most significantly upregulated and downregulated genes by fenofibrate were ranked according to statistical significance (IBMT P-value). The changes in gene expression are expressed relative to the mean of the control group as a signal log ratio