Fig. 5

Pathway analysis of differential gene expression between control-treated and fenofibrate-treated hepatocyte humanized mice. Transcriptomics was performed on livers of hepatocyte humanized mice treated with 300 mg/kg fenofibrate daily for 4 days (n = 3) or vehicle (control, n = 3). Genes that were significantly upregulated (red bars) or downregulated (blue bars) by fenofibrate (IBMT P-value< 0.005) were imported into the Enrichr tool (http://amp.pharm.mssm.edu/Enrichr/index.html) [31, 32]. The 10 pathways with the highest combined score are shown, in the following specific categories: KEGG, WikiPathways, Reactome, Gene ontology