Fig. 6
Comparative analysis of the effect of fenofibrate in normal mouse liver and hepatocyte humanized liver. Volcano plots in which 2log(fold-change) is plotted against -10log(P-value) for a Treatment of chimeric mice containing hepatocyte humanized livers with 300 mg/kg fenofibrate daily for 4 days as compared to control (n = 3 per group); b Treatment of wildtype mice with fenofibrate for 14 days via the feed (0.03 wt/wt, equivalent to approximately 1 mg/mouse/day) as compared to control (n = 8 per group); c Treatment of wildtype mice with fenofibrate for 6 h via a single oral gavage of 4 mg/mouse as compared to control (n = 4–5 per group)