Fig. 7

Comparative pathway analysis of the effect of fenofibrate in normal mouse liver and hepatocyte humanized liver. Gene set enrichment analysis was performed on the effect of treatment of chimeric mice containing hepatocyte humanized livers with 300 mg/kg fenofibrate daily for 4 days (n = 3 per group), and on the effect of treatment of wildtype mice with fenofibrate for 14 days via the feed (0.03 wt/wt, equivalent to approximately 1 mg/mouse/day, n = 8 per group). The top 20 most highly upregulated and downregulated genesets are shown, ranked according to normalized enrichment score. a The top 20 most highly upregulated genesets in hepatocyte humanized livers (left panel) and normal mouse livers (right panel). b The top 20 most highly downregulated genesets in hepatocyte humanized livers (left panel) and normal mouse livers (right panel). Genesets related to cytokine/interferon signalling are shown in green, genesets related to PPAR signalling and fatty acid oxidation are in red, genesets related to cholesterol synthesis are in grey, genesets related to DNA synthesis in orange, genesets related to complement and coagulation in violet