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Fig. 8 | BMC Genomics

Fig. 8

From: The whole transcriptome effects of the PPARα agonist fenofibrate on livers of hepatocyte humanized mice

Fig. 8

Effect of fenofibrate on specific genesets in normal mouse liver and hepatocyte humanized liver. Gene set enrichment analysis was performed on the effect of treatment of chimeric mice containing hepatocyte humanized livers with 300 mg/kg fenofibrate daily for 4 days (n = 3 per group). The 10 most highly ranked genes in the genesets KEGG.FATTY.ACID. DEGRADATION, INTERFERON.ALPHA.BETA.SIGNALING, KEGG.COMPLEMENT. COAGULATION, and DNA.STRAND.ELONGATION are shown. In parallel, expression changes of the same genes are shown in wildtype mice treated with fenofibrate for 14 days via the feed (0.03 wt/wt, equivalent to approximately 1 mg/mouse/day, n = 8 per group)

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BMC Genomics

ISSN: 1471-2164

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