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Table 1 Candidate genes that resulted in germline hyperplasia during the dauer stage following RNAi

From: Genome-wide surveys reveal polarity and cytoskeletal regulators mediate LKB1-associated germline stem cell quiescence

Chromosome

Cosmid identifier

Gene

Brief description

I

ZC123.3

 

Homeobox protein; homologue to human ATBF1 transcription factor and tumour suppressor

I

Y110A7A.10a

aap-1

PI3K p50/55 adaptor/regulatory subunit orthologue

I

T08B2.10

rps-17

40S ribosomal protein S17

I

F57B10.8

 

Activator of basal transcription

I

F26E4.4a

 

Activator of basal transcription

I

T06G6.9a

pfd-3

Molecular chaperon Prefoldin, subunit 3; orthologue to human VHL-binding protein tumour suppressor

I

Y87G2A.ha

gpi-1

Putative glucose 6-phosphate isomerase; Required for normally short lifespan

II

C23H3.4a

sptl-1

Putative serine palmitoyltransferase

II

F53A10.2

 

Rap-1 GTPase-activating protein; orthologue to a human tumour suppressor in squamous cell carcinoma

II

T05C1.6a

 

Calmodulin-binding transcriptional activator

II

R07G3.1

cdc-42

RHO small GTPase; regulator of polarity

II

T05C12.6

mig-5

One of three homologues to Dishevelled in Drosophila

II

T22C8.2

chhy-1

Chondroitin hydrolase; similar to human HYAL1, a potential tumour suppressor in lung cancer cell lines

II

F40F8.9a

lsm-1

Small nuclear ribonucleoprotein splicing factor

II

T06D8.2a

 

No description available

II

C50E10.3a

sre-53

G protein-coupled chemoreceptor

II

W01D2.2

nhr-61

Nuclear hormone receptor

III

R74.2a

 

No description available

III

Y44F5A.1

 

Protein containing WD40 repeats; required for protein-protein interactions

III

C27F2.4a

 

Predicted protein carboxyl methylase

III

R02F2.7a

 

No description available

III

F54E7.3

par-3

PDZ-domain containing protein; required for polarization of the early embryo

III

B0336.3a

 

Protein containing and RNA recognition motif

III

C07H6.5

cgh-1

Putative RNA helicase; inhibits apoptosis in oocytes

III

C50C3.9a

unc-36

Voltage-dependent calcium ion channe

III

Y52D3.1

strd-1

Activator of LKB1

IV

F15E6.8

dct-7

RNA binding protein controlled by DAF-16/FOXO; affects germline tumours

IV

H35B03.2a

 

Subunit of nuclear ribonuclease P

IV

C06E7.1a

sams-3

S-adenosylmethionine synthetase

IV

F12F6.5

sgrp-1

Homologue to Cdc42-interacting protein CIP4

IV

Y51H4A.c

rho-1

Rho GTPase; required for actin filament-based processes including embryonic polarity

V

F48G7.9

 

Serine/threonine protein kinase

V

C39F7.4

rab-1

Ras-like GTPase, orthologue to Rab1

V

T03D3.11a

srj-44

7-transmembrane olfactory receptor

V

F26D11.11a

let-413

Localizes to basolateral region of epithelial cells and required for adherens junction formation; strong homology to Drosophila Scribble

X

C14A11.3

cgef-1

Guanosine nucleotide exchange factor for Rho and Rac GTPases

X

C38C5.1a

 

No description available

X

F13B9.5

ksr-1

Kinase suppressor of Ras

X

T09B9.3a

 

Glycerophosphoryl diester phosphodiesterase

  1. The gene identity of each RNAi clone was determined by the database available with the commercially available Ahringer RNAi library. The brief descriptions for each gene locus are derived from WormBase or determined according to their functional homology
  2. aRNA candidates that potentially function germline non-autonomously