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Table 4 Psychiatric Genetics Consortium data, with varying amounts of overlapping controls

From: A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework

#Overlapping

Correlation

#Discoveries, raw

#Discoveries, adjusted

0

0

255.3 (239.8,270.8)

256.5 (239.7,273.3)

2000

0.09

322.3 (310.1,334.5)

206.5 (190.1, 222.9)

4000

0.18

479 (437.4,520.6)

194.5 (172.8, 216.2)

6000

0.27

827.6 (762.1, 893.1)

186.4 (162.9, 209.9

8000

0.36

1442.7 (1325.2, 1560.2)

188.9 (156.8, 221.0)

10000

0.45

2985.7 (2785.6, 3185.8)

212.7 (181.3, 244.1)

  1. The test statistics for bipolar disorder were used as a covariate for schizophrenia in the covariate-modulated fdr (cmfdr). SNPs having a cmfdr < 0.05 were called as discoveries. Data is presented as mean (95% confidence interval)