Plasma small ncRNA pair panels as novel biomarkers for early-stage lung adenocarcinoma screening

BMC Genomics

Table 4 Predictive values of small ncRNA pair panels at the training and validation stages

Small ncRNA pair panels	Sample size	SEN	SPE	PPV	NPV	FPR	FNR	AUC
Panel 1: LAC+Benign vs. Control
Training	85 vs. 29	1.000	1.000	1.000	1.000	0.000	0.000	1.000
Validation	76 vs. 51	0.915	0.804	0.855	0.882	0.196	0.085	0.902
Panel 1: LAC vs. Control
Training	50 vs. 29	1.000	1.000	1.000	1.000	0.000	0.000	1.000
Validation	44 vs. 51	0.854	0.833	0.795	0.882	0.167	0.146	0.895
Panel 2: LAC vs. Benign
Training	50 vs. 35	0.811	0.781	0.860	0.714	0.219	0.189	0.820
Validation	44 vs. 32	0.704	0.727	0.864	0.500	0.273	0.296	0.742

AUC area under receiver operating characteristic curve, FNR false negative rate, FPR false positive rate, LAC lung adenocarcinoma, NPV negative predictive value, PPV positive predictive value, SEN sensitivity, SPE specificity

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