Fig. 3

Query modules allow for in-depth exploration of antibiotic resistance. Hypothesis driven visualization based on a user-defined list of antibiotic resistance-related families in the 47 human microbiome samples indicated in Fig. 2. a sample output from the ‘Query Your Data’ module, including relative abundance levels of antibiotic resistance related GO-terms across samples. b pairwise statistical significance between sites for selected GO terms. c Taxa contributing to specific GO terms across samples. d Correlation of pathways in stool samples for a user-defined gene list aimed to elucidate relationships in abundance profiles across antibiotic-resistance mechanisms. Asterisks indicate statistical significance (*p < 0.05, **p < 0.01, ***p < 0.001). Columns/rows are labeled as shown to the right