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Table 3 Performance estimation of 5-fold cross validation and performance comparison with the existing methods

From: Transferring knowledge of bacterial protein interaction networks to predict pathogen targeted human genes and immune signaling pathways: a case study on M. tuberculosis

 

Size

Combined-instance

Homolog-instance

Target-instance

SP

SE

MCC

SP

SE

MCC

SP

SE

MCC

Positive

15,287

0.9823

0.9966

0.9790

0.9684

0.9915

0.9601

0.9820

0.9976

0.9796

Negative

15,287

0.9965

0.9821

0.9790

0.9912

0.9676

0.9601

0.9975

0.9817

0.9796

[Acc; MCC]

[98.93%; 0.9789]

[97.95%; 0.9599]

[97.95%; 0.9599]

[ROC-AUC]

[0.9933]

[0.9912]

[0.9978]

F1 Score

0.9894

0.9798

0.9897

KMM-SVM [23]

SP

SE

F1 score

① human- > mouse

0.517

0.937

0.667

② E.coli- > human

0.257

0.161

0.199

  1. â‘  denotes the work [23] that transfers the knowledge of Salmonella-human PPI networks to predict Salmonella-mouse protein interactions;â‘¡ denotes the work [23] that transfers the knowledge of Salmonella-Ecoli PPI networks to predict Salmonella-human protein interactions