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Table 3 Reactome pathway enrichment analysis results of miRNA target genes

From: The arrhythmogenic cardiomyopathy-specific coding and non-coding transcriptome in human cardiac stromal cells

Pathway name padj Count Size A B
Extracellular matrix organization 0.000 32 82 30 2
Assembly of collagen fibrils and other multimeric structures 0.000 14 22 14 0
Collagen formation 0.000 15 26 15 0
ECM proteoglycans 0.000 12 20 11 1
Non-integrin membrane-ECM interactions 0.000 13 25 13 0
Degradation of the extracellular matrix 0.000 16 42 15 1
Integrin cell surface interactions 0.000 14 33 13 1
Collagen biosynthesis and modifying enzymes 0.000 9 16 9 0
Platelet degranulation 0.001 11 29 10 1
Response to elevated platelet cytosolic Ca2+ 0.001 11 29 10 1
Collagen degradation 0.002 10 24 10 0
Platelet activation, signaling and aggregation 0.006 16 67 15 1
Elastic fibre formation 0.009 8 17 8 0
Laminin interactions 0.011 6 9 6 0
Collagen chain trimerization 0.012 7 13 7 0
Crosslinking of collagen fibrils 0.014 5 6 5 0
NCAM1 interactions 0.046 5 7 5 0
  1. Column p adj : p-value adjusted for multiple hypothesis testing using the method from Bonferroni assessing the significance of enrichment, Count and Size: number of target genes of ACM-miRNAs or of all detectable miRNAs associated with the pathway. Columns A and B contain the number of target genes of miR-29b-3p and miR-520c-3p