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Table 3 Reactome pathway enrichment analysis results of miRNA target genes

From: The arrhythmogenic cardiomyopathy-specific coding and non-coding transcriptome in human cardiac stromal cells

Pathway name

padj

Count

Size

A

B

Extracellular matrix organization

0.000

32

82

30

2

Assembly of collagen fibrils and other multimeric structures

0.000

14

22

14

0

Collagen formation

0.000

15

26

15

0

ECM proteoglycans

0.000

12

20

11

1

Non-integrin membrane-ECM interactions

0.000

13

25

13

0

Degradation of the extracellular matrix

0.000

16

42

15

1

Integrin cell surface interactions

0.000

14

33

13

1

Collagen biosynthesis and modifying enzymes

0.000

9

16

9

0

Platelet degranulation

0.001

11

29

10

1

Response to elevated platelet cytosolic Ca2+

0.001

11

29

10

1

Collagen degradation

0.002

10

24

10

0

Platelet activation, signaling and aggregation

0.006

16

67

15

1

Elastic fibre formation

0.009

8

17

8

0

Laminin interactions

0.011

6

9

6

0

Collagen chain trimerization

0.012

7

13

7

0

Crosslinking of collagen fibrils

0.014

5

6

5

0

NCAM1 interactions

0.046

5

7

5

0

  1. Column p adj : p-value adjusted for multiple hypothesis testing using the method from Bonferroni assessing the significance of enrichment, Count and Size: number of target genes of ACM-miRNAs or of all detectable miRNAs associated with the pathway. Columns A and B contain the number of target genes of miR-29b-3p and miR-520c-3p