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Fig. 1 | BMC Genomics

Fig. 1

From: Identification of sonic hedgehog-regulated genes and biological processes in the cranial neural crest mesenchyme by comparative transcriptomics

Fig. 1

Schematic of Shh pathway activation in cNCCs in vivo and in vitro. a Pseudo-colored scanning electron micrographs of GD9.25, 10.25, 11.25, and 14.0 mouse embryos show the dynamic morphological changes of orofacial development. Embryos not in exact scale. b Schematic of GD9.25 embryo being cut mid-sagittally to reveal the cross-section in (c). c Schematic showing normal Shh pathway activity in vivo in GD9.25 FNP tissue. SHH ligand secreted from the surface and neural ectoderm activates post-migratory cNCC-derived mesenchymal cells in facial primordia (green shading), leading to regulation of Shh target genes, like Gli1 (positively regulated by Shh signaling) and Gas1 (negatively regulated by Shh signaling). d Schematic of in vitro cNCC Shh pathway activation by addition of SHH ligand, which alters expression of Shh-regulated genes in the SHH-responding cNCCs

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