Fig. 3
Enrichment analysis of Shh-regulated genes in cNCCs in vitro. a Functional enrichment analysis of 2749 genes that are significantly dysregulated in cNCCs stimulated by SHH in vitro. Each selected functional category is significantly enriched within the differentially expressed gene set. b-g Hierarchically clustered heat maps for significantly enriched biological categories showing the specific significantly dysregulated genes (FDR p-value < 0.01) in each biological category. Gli1 is highlighted in (b). Heat maps represent log10 signal intensity for each gene in each condition, which are then clustered by biological response. Yellow represents genes with higher expression while blue represents genes with lower expression. N = 4 biological replicates (1–4)