Identification of sonic hedgehog-regulated genes and biological processes in the cranial neural crest mesenchyme by comparative transcriptomics

Table 2 Top negatively Shh-regulated concordant genes

Rank	Gene Symbol	In vitro FC (SHH/Veh)	In vitro FDR p-value	In vivo FC (Veh/Cyc)	In vivo FDR p-value
1	Edn1	0.262467192	0.000042	0.680272109	0.195648
2	Gprc5a	0.408163265	0.000156	0.81300813	0.730671
3	Aoc3	0.259067358	0.00002	0.847457627	0.725263
4	Stambpl1	0.409836066	0.000181	0.833333333	0.654448
5	Slc38a4	0.408163265	0.004794	0.833333333	0.737329
6	St6galnac2	0.487804878	0.00094	0.81300813	0.714645
7	Gas1	0.261096606	0.000085	0.854700855	0.749637
8	Grem1	0.423728814	0.000056	0.833333333	0.641684
9	Bnc1	0.502512563	0.000752	0.833333333	0.226873
10	Adamts9	0.462962963	0.000004	0.854700855	0.448794
11	Lhfp	0.558659218	0.000247	0.840336134	0.723333
12	Mylk	0.529100529	0.000042	0.847457627	0.32826
13	Cacnb2	0.414937759	0.000106	0.869565217	0.618111
14	H2-Q9	0.564971751	0.00101	0.847457627	0.170192
15	Prkg1	0.595238095	0.00159	0.840336134	0.488058
16	Cadm1	0.411522634	0.000029	0.877192982	0.749129
17	Nrp2	0.666666667	0.000395	0.769230769	0.685182
18	B4galnt1	0.694444444	0.000643	0.763358779	0.560523
19	Pamr1	0.531914894	0.004349	0.862068966	0.723333
20	Npnt	0.344827586	0.000037	0.909090909	0.448794
21	Ak4	0.41322314	0.000639	0.909090909	0.158579
22	Pard6b	0.406504065	0.000074	0.917431193	0.707119
23	Aldoc	0.751879699	0.001536	0.819672131	0.618111
24	Slc1a4	0.584795322	0.002363	0.892857143	0.730671
25	Nfkbiz	0.636942675	0.000028	0.884955752	0.661155
26	Mast4	0.558659218	0.000588	0.900900901	0.618111
27	Maml2	0.454545455	0.000009	0.917431193	0.618111
28	Syde2	0.78125	0.007317	0.826446281	0.704734
29	Lpar4	0.689655172	0.000181	0.877192982	0.317827
30	Lamb1	0.694444444	0.000362	0.877192982	0.155497

ISSN: 1471-2164