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Fig. 3 | BMC Genomics

Fig. 3

From: Development and validation of an updated computational model of Streptomyces coelicolor primary and secondary metabolism

Fig. 3

Correlation analysis between gene expression and predicted fluxes for the different models. The histograms show correlations between gene expression and flux predicted for the metabolic genes present in the different published GSMMs of S. coelicolor. This approach has been used first by Alam et al. [21], for the model iMA789. a Histogram of correlations for the model iMA789 by Alam et al. [21]. b Histogram of correlations for the model iMK1208 by Kim et al. [22]. c Histogram of correlations for the new model, iAA1259. The histogram shows a strong correlation between gene expression and predicted fluxes for metabolic genes present in the model iAA1259. Overall correlation is substantially higher than for the previous models, with a median Spearman correlation of 0.56 compared to 0.13 for iMA789 and 0.18 for iMK1208. d Histogram of correlations for the model iAA1259, but only taking into account genes with expression variation of more than 25% between the minimal and maximal transcript level

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