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Fig. 2 | BMC Genomics

Fig. 2

From: Germline and somatic variations influence the somatic mutational signatures of esophageal squamous cell carcinomas in a Chinese population

Fig. 2

The mutational processes in ESCC are associated with subpopulations of Chinese, tobacco and alcohol exposure. Comparison of the activities of the “NpCpG” signature (a), the “Background” signature (b) and the frequency of C > A (c) and T > C (d) substitutions in CHBs and CHSs. The subpopulations are determined based on the reference populations of CHS and CHB from the TGP. Comparison of the activities of the “NpCpG” mutational signatures (e) and the frequencies of T > C substitutions (f) against the alcohol exposure. And comparison of the frequencies of C > A substitutions (g) and the frequencies of T > C substitutions (h) with tobacco exposure. The FDR is based on the adjusted Wilcoxon rank-sum test P values

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BMC Genomics

ISSN: 1471-2164

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