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Table 3 Results of 10–fold cross validation of SVM model on 12,157 PPIs between any host-virus PPIs with different ratios of positive to negative instances

From: A generalized approach to predicting protein-protein interactions between virus and host

P:N Dataset SN(%) SP(%) ACC(%) PPV(%) NPV(%) MCC AUC
  1 84.93 86.03 85.48 85.87 85.09 0.709 0.926
1:1 2 84.92 86.06 85.49 85.89 85.09 0.701 0.926
  3 85.36 85.92 85.64 85.84 85.44 0.712 0.925
  mean  ± SD 85.07  ± 0.3 86.00  ± 0.1 85.54  ± 0.1 85.87  ± 0.0 85.21  ± 0.2 0.71  ± 0.0 0.93  ± 0.0
  1 78.91 91.17 87.08 81.72 89.64 0.707 0.923
1:2 2 78.29 91.03 86.78 81.36 89.34 0.700 0.921
  3 78.22 91.18 86.86 81.59 89.33 0.701 0.920
  mean  ± SD 78.47  ± 0.4 91.13  ± 0.1 86.91  ± 0.2 81.56  ± 0.2 89.44  ± 0.2 0.70  ± 0.0 0.92  ± 0.0
  1 74.55 93.32 88.63 78.82 91.66 0.691 0.920
1:3 2 74.61 93.56 88.82 79.43 91.70 0.696 0.919
  3 74.62 93.41 88.72 79.07 91.69 0.693 0.920
  mean  ± SD 74.59  ± 0.0 93.43  ± 0.1 88.72  ± 0.1 79.11  ± 0.3 91.68  ± 0.0 0.69  ± 0.0 0.92  ± 0.0
  1. SN: sensitivity, SP: specificity, ACC: accuracy, PPV: positive predictive value, NPV: negative predictive value, MCC: Matthews correlation coefficient, AUC: the area under the ROC