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Table 5 Results of testing the prediction model on PPIs of new viruses

From: A generalized approach to predicting protein-protein interactions between virus and host

Dataset SN(%) SP(%) ACC(%) PPV(%) NPV(%) MCC AUC
TR1–TS1 89.76 66.14 77.95 72.61 86.60 0.575 0.886
TR2–TS2 90.67 65.33 78.00 72.34 87.50 0.579 0.867
TR3–TS1 88.98 65.88 77.43 72.28 85.67 0.564 0.884
TR4–TS2 94.67 68.67 81.67 75.13 92.79 0.656 0.890
  1. TR1: training dataset of PPIs between human and any virus except H1N1. TS1: test dataset of PPIs between human and H1N1 virus. TR2: training dataset of PPIs between human and any virus except Ebola virus. TS2: test dataset of PPIs between human and Ebola virus. TR3: training dataset of PPIs between any host and any virus except H1N1. TR4: training dataset of PPIs between any host and any virus except Ebola virus. SN: sensitivity, SP: specificity, ACC: accuracy, PPV: positive predictive value, NPV: negative predictive value, MCC: Matthews correlation coefficient, AUC: area under the ROC