A generalized approach to predicting protein-protein interactions between virus and host

BMC Genomics

Table 6 Results of testing the prediction models trained with human-virus PPIs (TR5) on PPIs of new hosts

Dataset	SN(%)	SP(%)	ACC(%)	PPV(%)	NPV(%)	MCC	AUC
TR5–TS5.1	66.39	65.98	66.19	66.12	66.26	0.324	0.733
TR5–TS5.2	76.47	58.82	67.65	65.00	71.43	0.359	0.761
TR5–TS5.3	59.44	74.83	67.13	70.25	64.85	0.347	0.736
TR5–TS5.4	64.87	67.87	66.37	66.87	65.89	0.327	0.731

TS5.1: test dataset of PPIs between non-human animal and any virus. TS5.2: test dataset of PPIs between plant and any virus. TS5.3: test dataset of PPIs between bacteria and any virus. TS5.4: test dataset of PPIs between any non-human host (non-human animal, plant, bacteria and 15 other hosts) and any virus. SN: sensitivity, SP: specificity, ACC: accuracy, PPV: positive predictive value, NPV: negative predictive value, MCC: Matthews correlation coefficient, AUC: the area under the ROC

ISSN: 1471-2164