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Fig. 2 | BMC Genomics

Fig. 2

From: Gene expression analysis indicates reduced memory and cognitive functions in the hippocampus and increase in synaptic reorganization in the frontal cortex 3 weeks after MDMA administration in Dark Agouti rats

Fig. 2

Network Analysis of the GSEA Results in the Hippocampus. The network shows significantly (nominal p < 0.05, false discovery rate < 0.25) enriched gene ontology (GO) terms in the gene set enrichment (GSEA) analysis in the hippocampus (HC) of Dark Agouti rats 3 weeks after a single-dose (15 mg/kg, intraperitoneal) 3,4-methylenedioxymethamphetamine (MDMA) administration. Blue circles represent the downregulation of the associated terms, while red circles would represent upregulations. The size of the nodes is proportional with the number of genes in the GO term and the thickness of the edges between lines represents the similarity coefficient. All processes in the HC are downregulated, and two well characterized groups of processes emerge. On one hand the processes related to cognition and memory, e.g. regulation of synaptic plasticity, dendrite development and regulation of glutamatergic synaptic transmission gene sets form a diverse group. On the other hand the processes related to kinase activity form another network. See text for further details

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BMC Genomics

ISSN: 1471-2164

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