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Table 1 Selection of significantly altered genes by single-dose MDMA treatment in the different brain regions

From: Gene expression analysis indicates reduced memory and cognitive functions in the hippocampus and increase in synaptic reorganization in the frontal cortex 3 weeks after MDMA administration in Dark Agouti rats

  MinPplr Fold Change (on log2 scale)
Frontal Cortex
 Camk2g Calcium/calmodulin-dependent protein kinase II gamma 0.000127 0.900
 Camk1g Calcium/calmodulin-dependent protein kinase I gamma 0.000174 0.383
 Grin2b Glutamate receptor, ionotropic, NMDA2B (Grin2b) 0.000395 0.448
 Hspca Heat shock protein 90α 0.000677 −0.398
 Slc1a3 Solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.000417 −0.724
Hippocampus
 Gria3 Glutamate receptor, ionotropic, AMPA3 5.23E-05 −0.916
 Grin2a Glutamate receptor, ionotropic, N-methyl D-aspartate 2A 5.42E-08 −1.610
 Camk2g Calcium/calmodulin-dependent protein kinase II gamma 1.46E-08 −1.451
 Camk2b Calcium/calmodulin-dependent protein kinase II beta 1.02E-08 −1.751
 Kalrn Kalirin, RhoGEF kinase 2.69E-05 −0.419
 LOC316539 Eph receptor A4 1.82E-05 −0.729
 Epha5 Eph receptor A5 3.29E-09 −1.065
 Epha6 Eph receptor A6 7.39E-05 −0.484
 Camk2n2 Calcium/calmodulin-dependent protein kinase II inhibitor 2 3.44E-06 0.345
 Gabre Gamma-aminobutyric acid A receptor, epsilon 0.000525 0.268
 Atp2b3 ATPase, Ca++ transporting, plasma membrane 3 2.41E-12 −0.567
 Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 1.16E-05 −0.863
 Slc5a3 Solute carrier family 5 (inositol transporters), member 3 9.94E-10 −1.356
 Kcnd2 Potassium voltage gated channel, Shal-related family, member 2 7.56E-07 −1.476
 Kcnc2 Potassium voltage gated channel, Shaw-related subfamily, member 2 6.11E-07 −0.905
 Cnr1 Cannabinoid receptor 1 3.1E-06 −0.793
Dorsal Raphe
 Slc6a5 Solute carrier family 6 (neurotransmitter transporter, glycine), member 5 0.000153 1.143
 Hsd11b1 Hydroxysteroid 11-beta dehydrogenase 1 1.19E-08 0.450
 Dao1 D-amino acid oxidase 0.000384 0.451
  1. This table summarizes the genes significantly (minimum probability of positive log ratio (MinPplr) < 0.001) altered in the frontal cortex (FC), hippocampus (HC) and dorsal raphe (DR) of Dark Agouti (DA) rats after a single-dose 3,4-methylenedioxymethamphetamine (MDMA) treatment (15 mg/kg, intraperitoneal) 3 weeks earlier. The genes were selected based on literature data and individual considerations, for all the significantly changed genes see Additional file 1: Table S1. See text for further details
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BMC Genomics

ISSN: 1471-2164

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