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Fig. 5 | BMC Genomics

Fig. 5

From: Understanding the role of interactions between host and Mycobacterium tuberculosis under hypoxic condition: an in silico approach

Fig. 5

Plots depicting change in reaction fluxes during hypoxia versus lengths of shortest paths connecting metabolic enzymes to HPI and GRN networks. Plots depicting the magnitude of change in reaction fluxes during hypoxia (obtained using FBA simulations) versus the lengths of shortest paths (path lengths) connecting the corresponding enzymes to (a) M. tuberculosis H37Rv (Mtb) proteins involved in HPIs, and (b) transcription factors in the hypoxia gene regulatory network of Mtb. The median (red line), IQR (box), 1.5 × IQR (whisker), and outliers (red asterisks) corresponding to flux fold change values are indicated in the plot. The plot indicates that metabolic enzymes associated with reactions experiencing higher fold changes during hypoxia are more closely connected (in terms of shorter path lengths) to the proteins involved in HPIs, as compared to the transcription factors known to regulate hypoxic response

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