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Table 3 Significantly enriched GO Terms for the three vocabularies obtained via ClueGO (FDR < 0.05)

From: Dietary supplementation with olive mill wastewaters induces modifications on chicken jejunum epithelial cell transcriptome and modulates jejunum morphology

GO-ID

GO-Term

FDR

Nr. Genes

Associated Genes Found

GO:0006066

alcohol metabolic process

2,30E-04

11,00

[ABHD3, CHDH, CHPT1, CYP51A1, DHCR24, ENPP7, FDPS, HMGCS1, INSIG1, MSMO1, NSDHL]

GO:0016126

sterol biosynthetic process

2,70E-04

5,00

[CYP51A1, FDPS, HMGCS1, INSIG1, MSMO1]

GO:0000793

condensed chromosome

3,30E-04

8,00

[BRCA1, CENPW, MSH4, NDC80, NEK2, PLK1, SGOL1, SMC2]

GO:1901615

organic hydroxy compound metabolic process

3,40E-04

13,00

[ABHD3, ALDH9A1, BBOX1, CHDH, CHPT1, CYP51A1, DHCR24, ENPP7, FDPS, HMGCS1, INSIG1, MSMO1, NSDHL]

GO:0008610

lipid biosynthetic process

3,70E-04

14,00

[AGMO, BRCA1, CHPT1, CYP51A1, FDFT1, FDPS, GPAM, HMGCS1, INSIG1, MSMO1, NSDHL, PIGA, PLD1, TCF7L2]

GO:0016125

sterol metabolic process

3,80E-04

7,00

[CYP51A1, DHCR24, FDPS, HMGCS1, INSIG1, MSMO1, NSDHL]

GO:0000794

condensed nuclear chromosome

4,00E-04

6,00

[BRCA1, MSH4, NDC80, NEK2, PLK1, SGOL1]

GO:0008203

cholesterol metabolic process

6,20E-04

6,00

[CYP51A1, DHCR24, FDPS, HMGCS1, INSIG1, NSDHL]

GO:1902652

secondary alcohol metabolic process

6,90E-04

6,00

[CYP51A1, DHCR24, FDPS, HMGCS1, INSIG1, NSDHL]

GO:0006695

cholesterol biosynthetic process

7,20E-04

4,00

[CYP51A1, FDPS, HMGCS1, INSIG1]

GO:1902653

secondary alcohol biosynthetic process

7,20E-04

4,00

[CYP51A1, FDPS, HMGCS1, INSIG1]

GO:0006577

amino-acid betaine metabolic process

1,10E-03

3,00

[ALDH9A1, BBOX1, CHDH]

GO:0006631

fatty acid metabolic process

1,10E-03

9,00

[AACS, AGMO, BRCA1, ETFA, GPAM, HADHA, INSIG1, MSMO1, SLC27A4]

GO:0051297

centrosome organization

1,20E-03

6,00

[BRCA1, HAUS8, NEK2, NPM1, PLK1, SGOL1]

GO:0032787

monocarboxylic acid metabolic process

1,20E-03

12,00

[AACS, AGMO, ALDH9A1, BBOX1, BRCA1, ETFA, GPAM, HADHA, INSIG1, MSMO1, SLC27A4, VNN1]

GO:0098813

nuclear chromosome segregation

1,30E-03

8,00

[MSH4, NDC80, NEK2, NUSAP1, PLK1, SGOL1, SMC2, UBE2C]

GO:0007059

chromosome segregation

1,50E-03

9,00

[BRCA1, MSH4, NDC80, NEK2, NUSAP1, PLK1, SGOL1, SMC2, UBE2C]

GO:0000780

condensed nuclear chromosome, centromeric region

1,50E-03

3,00

[NDC80, PLK1, SGOL1]

GO:0031023

microtubule organizing center organization

1,50E-03

6,00

[BRCA1, HAUS8, NEK2, NPM1, PLK1, SGOL1]

GO:0046165

alcohol biosynthetic process

1,60E-03

6,00

[CHPT1, CYP51A1, FDPS, HMGCS1, INSIG1, MSMO1]

GO:0006576

cellular biogenic amine metabolic process

1,60E-03

5,00

[ABHD3, CHDH, CHPT1, ENPP7, SMOX]

GO:0045132

meiotic chromosome segregation

1,90E-03

4,00

[MSH4, PLK1, SGOL1, SMC2]

GO:0042439

ethanolamine-containing compound metabolic process

2,20E-03

4,00

[ABHD3, CHDH, CHPT1, ENPP7]

GO:1901617

organic hydroxy compound biosynthetic process

2,20E-03

7,00

[BBOX1, CHPT1, CYP51A1, FDPS, HMGCS1, INSIG1, MSMO1]

GO:0000070

mitotic sister chromatid segregation

2,30E-03

6,00

[NDC80, NEK2, NUSAP1, PLK1, SMC2, UBE2C]

GO:0097164

ammonium ion metabolic process

2,70E-03

6,00

[ABHD3, ALDH9A1, BBOX1, CHDH, CHPT1, ENPP7]

GO:0008608

attachment of spindle microtubules to kinetochore

2,80E-03

3,00

[NDC80, NEK2, SGOL1]

GO:0000779

condensed chromosome, centromeric region

3,10E-03

4,00

[CENPW, NDC80, PLK1, SGOL1]

GO:0045071

negative regulation of viral genome replication

3,10E-03

3,00

[EIF2AK2, OASL, RSAD2]

GO:0009308

amine metabolic process

4,00E-03

5,00

[ABHD3, CHDH, CHPT1, ENPP7, SMOX]

GO:0003725

double-stranded RNA binding

4,00E-03

4,00

[DHX58, EIF2AK2, OASL, TLR3]

GO:0008202

steroid metabolic process

4,00E-03

7,00

[CYP51A1, DHCR24, FDPS, HMGCS1, INSIG1, MSMO1, NSDHL]

GO:0044106

cellular amine metabolic process

4,10E-03

5,00

[ABHD3, CHDH, CHPT1, ENPP7, SMOX]

GO:0000281

mitotic cytokinesis

4,10E-03

3,00

[MITD1, NUSAP1, PLK1]

GO:0009615

response to virus

4,60E-03

8,00

[DDX60, DHX58, EIF2AK2, GPAM, IKBKE, OASL, RSAD2, TLR3]

GO:0000819

sister chromatid segregation

4,70E-03

6,00

[NDC80, NEK2, NUSAP1, PLK1, SMC2, UBE2C]

GO:0000776

kinetochore

4,90E-03

5,00

[CENPW, NDC80, NEK2, PLK1, SGOL1]

GO:1904030

negative regulation of cyclin-dependent protein kinase activity

7,70E-03

3,00

[NPM1, PLK1, UBE2C]

GO:0008654

phospholipid biosynthetic process

8,40E-03

5,00

[CHPT1, FDPS, GPAM, PIGA, PLD1]

GO:0061640

cytoskeleton-dependent cytokinesis

8,50E-03

3,00

[MITD1, NUSAP1, PLK1]

GO:0000777

condensed chromosome kinetochore

9,10E-03

3,00

[CENPW, NDC80, PLK1]

GO:0045840

positive regulation of mitotic nuclear division

9,10E-03

3,00

[NUSAP1, PLK1, UBE2C]

GO:0072330

monocarboxylic acid biosynthetic process

1,00E-02

5,00

[AGMO, BBOX1, BRCA1, INSIG1, MSMO1]

GO:0046486

glycerolipid metabolic process

1,20E-02

7,00

[ABHD3, CHPT1, GPAM, INSIG1, PIGA, PLD1, TCF7L2]

GO:0044242

cellular lipid catabolic process

1,30E-02

5,00

[ENPP7, ETFA, GALC, HADHA, SLC27A4]

GO:0098661

inorganic anion transmembrane transport

1,30E-02

4,00

[ANO6, LOC101748788, SLC20A1, SLC26A2]

GO:1903901

negative regulation of viral life cycle

1,40E-02

3,00

[EIF2AK2, OASL, RSAD2]

GO:0008081

phosphoric diester hydrolase activity

1,40E-02

4,00

[ENPP7, GDPD1, PDE9A, PLD1]

GO:0051785

positive regulation of nuclear division

1,40E-02

3,00

[NUSAP1, PLK1, UBE2C]

GO:0051607

defense response to virus

1,50E-02

6,00

[DDX60, DHX58, GPAM, OASL, RSAD2, TLR3]

GO:0006633

fatty acid biosynthetic process

1,50E-02

4,00

[AGMO, BRCA1, INSIG1, MSMO1]

GO:0015103

inorganic anion transmembrane transporter activity

1,50E-02

4,00

[ANO6, LOC101748788, SLC20A1, SLC26A2]

GO:0045069

regulation of viral genome replication

1,50E-02

3,00

[EIF2AK2, OASL, RSAD2]

GO:0000922

spindle pole

1,50E-02

4,00

[NEK2, NPM1, PLK1, SGOL1]

GO:0048806

genitalia development

1,60E-02

3,00

[DHCR24, KLHL10, TCF7L2]

GO:0048525

negative regulation of viral process

1,70E-02

3,00

[EIF2AK2, OASL, RSAD2]

GO:1902850

microtubule cytoskeleton organization involved in mitosis

1,80E-02

3,00

[NDC80, NEK2, PLK1]

GO:0000775

chromosome, centromeric region

1,90E-02

5,00

[CENPW, NDC80, NEK2, PLK1, SGOL1]

GO:0022626

cytosolic ribosome

2,10E-02

4,00

[RP11-849F2.7, RPL21, RPL9, RPS23]

GO:0043901

negative regulation of multi-organism process

2,10E-02

4,00

[DHX58, EIF2AK2, OASL, RSAD2]

GO:1901989

positive regulation of cell cycle phase transition

2,10E-02

3,00

[NPM1, PLK1, UBE2C]

GO:0006641

triglyceride metabolic process

2,10E-02

3,00

[GPAM, INSIG1, TCF7L2]

GO:0090068

positive regulation of cell cycle process

2,20E-02

5,00

[BRCA1, NPM1, NUSAP1, PLK1, UBE2C]

GO:0009062

fatty acid catabolic process

2,30E-02

3,00

[ETFA, HADHA, SLC27A4]

GO:0016614

oxidoreductase activity, acting on CH-OH group of donors

2,30E-02

4,00

[CHDH, DHCR24, HADHA, NSDHL]

GO:0035725

sodium ion transmembrane transport

2,30E-02

4,00

[ANO6, CNKSR3, SLC20A1, STOML1]

GO:0019079

viral genome replication

2,30E-02

3,00

[EIF2AK2, OASL, RSAD2]

GO:0007126

meiotic nuclear division

2,40E-02

4,00

[MSH4, PLK1, SGOL1, SMC2]

GO:0022625

cytosolic large ribosomal subunit

2,60E-02

3,00

[RP11-849F2.7, RPL21, RPL9]

GO:0045017

glycerolipid biosynthetic process

2,60E-02

4,00

[CHPT1, PIGA, PLD1, TCF7L2]

GO:0006639

acylglycerol metabolic process

2,70E-02

3,00

[GPAM, INSIG1, TCF7L2]

GO:0045444

fat cell differentiation

2,80E-02

5,00

[FNDC5, INSIG1, PEX11A, SOCS1, TCF7L2]

GO:0015698

inorganic anion transport

2,80E-02

4,00

[ANO6, LOC101748788, SLC20A1, SLC26A2]

GO:0006638

neutral lipid metabolic process

2,80E-02

3,00

[GPAM, INSIG1, TCF7L2]

GO:0007051

spindle organization

2,80E-02

4,00

[HAUS8, NDC80, NEK2, PLK1]

GO:0007098

centrosome cycle

3,00E-02

3,00

[BRCA1, NEK2, NPM1]

GO:0005254

chloride channel activity

3,00E-02

3,00

[ANO6, LOC101748788, SLC26A2]

GO:1903046

meiotic cell cycle process

3,00E-02

4,00

[MSH4, PLK1, SGOL1, SMC2]

GO:0007052

mitotic spindle organization

3,30E-02

3,00

[NDC80, NEK2, PLK1]

GO:0051092

positive regulation of NF-kappaB transcription factor activity

3,30E-02

3,00

[EIF2AK2, NPM1, TLR3]

GO:0004386

helicase activity

3,40E-02

4,00

[DDX60, HELB, MOV10, PIF1]

GO:0072329

monocarboxylic acid catabolic process

3,40E-02

3,00

[ETFA, HADHA, SLC27A4]

GO:0004620

phospholipase activity

3,40E-02

3,00

[ABHD3, ENPP7, PLD1]

GO:0051983

regulation of chromosome segregation

3,40E-02

3,00

[NEK2, PLK1, UBE2C]

GO:0010565

regulation of cellular ketone metabolic process

3,50E-02

3,00

[BRCA1, INSIG1, TCF7L2]

GO:1902476

chloride transmembrane transport

3,60E-02

3,00

[ANO6, LOC101748788, SLC26A2]

GO:0051321

meiotic cell cycle

3,60E-02

4,00

[MSH4, PLK1, SGOL1, SMC2]

GO:0051225

spindle assembly

3,60E-02

3,00

[HAUS8, NEK2, PLK1]

GO:0005253

anion channel activity

3,70E-02

3,00

[ANO6, LOC101748788, SLC26A2]

GO:2001251

negative regulation of chromosome organization

3,70E-02

3,00

[BRCA1, PIF1, PLK1]

GO:0015297

antiporter activity

3,90E-02

3,00

[LOC101748788, SLC26A2, SLC7A4]

GO:0015108

chloride transmembrane transporter activity

3,90E-02

3,00

[ANO6, LOC101748788, SLC26A2]

GO:0050660

flavin adenine dinucleotide binding

3,90E-02

3,00

[CHDH, DHCR24, ETFA]

GO:0051053

negative regulation of DNA metabolic process

4,00E-02

3,00

[ENPP7, PIF1, POLQ]

GO:1904029

regulation of cyclin-dependent protein kinase activity

4,50E-02

3,00

[NPM1, PLK1, UBE2C]

GO:0008286

insulin receptor signaling pathway

4,80E-02

3,00

[IRS4, KL, SOCS1]

  1. GO-ID GO term accession number, GOTerm name of Gene Ontology Term, FDR (False Discovery Rate) after Benjamini-Hochberg correction, Nr. Genes number of input genes found per term, Associated Genes Found associated name of genes found per term