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Table 1 Genes in cluster 14 with known function

From: Combination of novel and public RNA-seq datasets to generate an mRNA expression atlas for the domestic chicken

Gene symbol Gene name Protein function References
AMZ1 archaemetzincin 1 metalloprotease, possibly involved in tissue remodelling to form feather follicles [141, 142]
ANKK1 (PKK2) ankyrin repeat and kinase domain containing 1 interacts with keratin filaments [143]
AREG amphiregulin epithelial growth factor [144]
CLDN9 claudin 9 tight junction membrane protein found in all epithelia [145]
DLX4 homeobox protein DLX4 homeobox protein that regulates epithelial-mesenchymal interactions [146]
EDMTF4 epidermal differentiation protein starting with MTF motif 4 markers of the feather barbule and members of the epidermal differentiation complex; this has a role in integumentary development, including feather pigmentation [147,148,149]
EDMTFH epidermal differentiation protein starting with MTF and rich in histidine
FK21 feather keratin 21 feather keratins  
FK27 feather keratin 27
PNPLA4 patatin-like phospholipase domain-containing protein 4 enzyme with a role in retinol metabolism (retinol and related compounds regulate epithelial cell growth and differentiation) [150, 151]
RAB38 Ras-related protein RAB38 GTPase involved in melanosome biogenesis and epithelial pigmentation [152, 153]
RASSF10 Ras association domain family member 10 tumour suppressor that mediates the epithelial-mesenchymal transition [154]
SDR16C5 (RDH-E2) epidermal retinol dehydrogenase 2 overexpressed in psoriatic human skin [155]
XG Xg blood group blood group antigen [156]