Table 1 DAVID functional annotation clusters for top 500 most abundant mRNA identified in oEVs
Most descriptive categories of DAVID functional annotation clusters groups by similar GO terms | #mRNA1 | Score2 |
|---|---|---|
GO Group 1: Protein translation and transport | 236 | 63 |
protein transport (145, 2.8)3, translation (129, 7.3), ribosome (87, 11.4), protein targeting to ER (81, 28.4), nuclear transport (29, 2.2), regulation of protein localization (40, 1.5) | Â | Â |
GO Group 2: Extracellular vesicles | 254 | 59.4 |
extracellular exosome (253, 3), extracellular vesicle (253, 3), phagocytosis (13, 1.7) | Â | Â |
GO Group 3: Gene expression | 314 | 46.5 |
RNA binding (203, 4.4), gene expression (244, 1.7), negative regulation of metabolic process (109, 1.6), negative regulation of transcription, DNA-templated (42, 1.4) | Â | Â |
GO Group 4: Cell adhesion | 139 | 40.5 |
adherens junction (112, 5.3), focal adhesion (77, 6.5), cadherin binding (51, 5.9) | Â | Â |
GO Group 5: Mitochondrion/oxidation-reduction | 131 | 7.4 |
mitochondrion (86, 1.7), generation of precursor metabolites and energy (37, 3.6), oxidation-reduction process (49, 1.8), ATP metabolic process (30, 4.5), oxidative phosphorylation (23, 4.2) | Â | Â |
GO Group 6: Apoptosis | 87 | 6 |
programmed cell death (87, 1.7), apoptotic signaling pathway (40, 2.5), apoptotic mitochondrial changes (10, 3.1) | Â | Â |
GO Group 7: ATPase/GTPase | 54 | 6 |
nucleoside-triphosphatase activity (51, 2.3), ATPase activity (23, 1.9), GTPase activity (21, 3.2), GTP binding (22, 2.0) | Â | Â |
GO Group 8: Response to stress | 172 | 5 |
cellular response to stress (78, 1.6), response to oxidative stress (28, 2.6), antioxidant activity (11, 4.9), reactive oxygen species metabolic process (16, 2.6), regulation of response to DNA damage stimulus (10, 2.3) | Â | Â |
GO Group 9: RNA processing/transport | 42 | 3.3 |
RNA splicing (29, 2.6), mRNA processing (25, 1.9), spliceosomal complex (14, 2.6), RNA localization (14, 2.4), nuclear export (10, 2.0) | Â | Â |
GO Group 10: Immune response, proteolysis | 112 | 3.2 |
immune response (59, 1.4), regulation of proteolysis (40, 2.1), regulation of mRNA stability (23, 4.8), regulation of cytokine production (26, 1.6), platelet activation (13, 2.9), regulation of peptidase activity (23, 2.1) | Â | Â |
GO Group 11: Cell cycle | 64 | 2.9 |
mitotic cell cycle (45, 1.7), regulation of cell cycle (40, 1.5) | Â | Â |
GO Group 12: Cytoskeleton | 71 | 2.7 |
cytoskeleton (50, 1.9), microtubule (21, 1.7), cytoskeleton organization (51, 1.6), actin cytoskeleton organization (28, 1.8), actin filament organization (18, 2.0) | Â | Â |
GO Group 13: Signal transduction, phosphorylation | 192 | 2.6 |
regulation of protein metabolic process (118, 1.7), signal transduction by protein phosphorylation (38, 1.6), intracellular signal transduction (88, 1.2), phosphorylation (75, 1.2), phosphorus metabolic process (105, 1.2) | Â | Â |
GO Group 14: Chromatin | 23 | 2.6 |
chromatin DNA binding (11, 3.8), protein-DNA complex assembly (15, 2.3), chromatin assembly (9, 2.0) | Â | Â |
GO Group 15: Development | 41 | 2.3 |
gland development (22, 1.9), reproductive system development (19, 1.6), developmental process involved in reproduction (25, 1.4) | Â | Â |
GO Group 16: Response to hormones, growth factors, nutrients | 80 | 2.2 |
response to organic cyclic compound (42, 1.7), response to steroid hormone (20, 1.9), response to nutrient levels (19, 1.7), response to growth factor (28, 1.6), response to glucocorticoid (12, 3.1), response to cAMP (8, 3.0) | Â | Â |
GO Group 17: Cell organization | 82 | 1.8 |
regulation of organelle organization (47, 1.5), regulation of cellular component organization (76, 1.2), cell leading edge (20, 1.9) | Â | Â |
GO Group 18: Others | 68 | 2.6 |
energy reserve metabolic process (11, 4.3), glycogen metabolic process (10, 4.6), isomerase activity (13, 2.8), muscle contraction (17, 1.9), organic acid metabolic process (37, 1.5) | Â | Â |