Fig. 1From: Identifying mixed Mycobacterium tuberculosis infections from whole genome sequence dataHeterozygous SNP plots for two clinical Malawi samples, illustrating the difference between clonal heterogeneity (a) and the signals of mixed infections (b). The x-axis represents contiguous SNPs across the genome (numbered sequentially) with heterozygous SNP calls, and the y-axis represents the proportion of non-reference alleles at that SNP. a shows no evidence of mixed infection, with read frequencies at heterozygous sites randomly distributed between 0 and 1. b demonstrates the characteristic pattern of mixed infection with two different strains, with the read frequencies clustering into two distinct clusters with means around 0.90 and 0.10, implying a 0.9/0.1 mixtureBack to article page