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Fig. 5 | BMC Genomics

Fig. 5

From: Identifying mixed Mycobacterium tuberculosis infections from whole genome sequence data

Fig. 5

A closer inspection of samples identified as pure with the Bayesian clustering approach but mixed with the heterozygous sites approach. a A frequency histogram of heterozygous sites in Malawi samples identified as mixed infection or pure strains with the Bayesian clustering approach. Sample ERR323056, classified as a pure strain with 69 heterozygous sites, is highlighted. b The plotted allele frequencies of reads at heterozygous sites for samples identified as mixed using heterozygous sites approach but as pure strains with the Bayesian clustering approach, with sample ERR323056 shown first. Although there is some evidence of the characteristic pattern of mixed infection in some samples, the signal from heterozygous sites is insufficient to identify these strains as mixed infections

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