Fig. 1
From: Unsupervised correction of gene-independent cell responses to CRISPR-Cas9 targeting
Heterogeneous gene-independent responses to CRISPR-Cas9 targeting. a Average logFC values of sgRNA within segments of equal CN (excluding FE and histones) for three cell lines. Each circle represents a CN segment of the indicated copy number. Asterisks mark the CN at which a significance difference (Welchs t-test, p < 0.05) is initially (starting point) and continuously (critical point) observed compared to logFC values at CN = 2. Box-plots show the median, inter-quartile ranges and 95% confidence intervals. b Same as for A but considering only non-expressed genes (FPKM < 0.05). (c,d,e) Segments of equal gene copy number and segments of equal sgRNA logFCs for selected chromosomes in three cell lines