Table 4 Fasting or Time of day response genes with regulatory variants overlapping GWAS signals of complex traits
Tissue | Exposure | GeneName | eQTL SNP | GWAS SNP | r2 | Trait |
|---|---|---|---|---|---|---|
Fat | Hours fasting | ADAM19 | rs11134789 | rs2277027 | 0.99 | Lung function FEV1/FVC Lung function FEV1/FVC in ever smokers |
Fat | Hours fasting | CTPS1 | rs12037263 | rs2802551 | 0.98 | Height |
Fat | Hours fasting | DNM3 | rs17277932 | rs17277932 | 1.00 | Height |
Fat | Hours fasting | HEMK1 | rs399484 | rs399484 | 1.00 | Height |
Fat | Hours fasting | PHLDB1 | rs10790255 | rs45565037 | 0.86 | Rheumatoid arthritis |
Fat | Hours fasting | PTGER4 | rs10440635 | rs10440635 | 1.00 | Crohns disease |
rs7720838 | 1.00 | inflammatory bowel disease Irritable bowel syndrome Self reported allergy | ||||
Fat | Hours fasting | TRIM27 | rs115864834 | rs429369 | 1.00 | Height |
Fat | Hours fasting | TSEN15 | rs1952256 | rs1046934 | 1.00 | Height |
Fat | Hours fasting & Time of day | SLC9A3R2 | rs3211995 | rs3211995 | 1.00 | Height |
Fat | Time of day | TNFAIP8 | rs11064 | rs1045241 | 0.99 | Waist hip ratio in females Waist to hip ratio adjusted for body mass index |
Skin | Hours fasting | TNNT2 | rs12564445 | rs12564445 | 1.00 | Cardiac Troponin T levels |