Murine host response to Neisseria gonorrhoeae upper genital tract infection reveals a common transcriptional signature, plus distinct inflammatory responses that vary between reproductive cycle phases

Table 1 Phase dependent genes are significantly associated with cell cycle processes

Gene set source and type	Gene Set Name	Normalized Enrichment Score (NES)
Reactome pathway	REACTOME_MITOTIC_M_M_G1_PHASES	2.86
Reactome pathway	REACTOME_CELL_CYCLE_MITOTIC	2.82
Reactome pathway	REACTOME_DNA_REPLICATION	2.80
Reactome pathway	REACTOME_CELL_CYCLE	2.76
KEGG pathway	KEGG_CELL_CYCLE	2.67
Reactome pathway	REACTOME_MITOTIC_PROMETAPHASE	2.66
Reactome pathway	REACTOME_G2_M_CHECKPOINTS	2.65
Reactome pathway	REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS	2.60
GO Biological Process	DNA_REPLICATION	2.57

The differential activity of biologic systems in those genes identified as having significant reproductive-cycle-phase-effected expression was evaluated by GSEA. The biological processes represented in the 732 gene sets identified by GSEA as containing genes whose expression demonstrated significant phase effect are reflected in these 10 most significantly associated gene sets. Gene sets are ranked in descending order by Normalized Enrichment score and are labeled according to the MSigDB sub-collection to which they belong. The full table of identified gene sets can be found in Additional file 2

ISSN: 1471-2164